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本文通过比较１０３例前列腺癌和９８例前列腺增生（ＢＰＨ）患者的总游离前列腺特异抗原（ＰＳＡ）和游离／总前列腺特异抗原比值（Ｆ／Ｔ比值），表明在包含所有患者时，前列腺癌组和 ＢＰＨ组患者血清总 ＰＳＡ水平和 Ｆ／Ｔ比值均有明显差异（Ｐ＜０．０１），但在总ＰＳＡ在４．０～１０．０ｎｇ／ｍｌ区间时，两组患者的总ＰＳＡ的水平无显著差异，而前列腺患者组的 Ｆ／Ｔ比值却明显低于 ＢＰＨ组（Ｐ＜０．０１）。通过对敏感性和特异性的分析表明，在总 ＰＳＡ４． ０～１０． ０ｎｇ／ｍｌ区间时，在相同的敏感性的情况下，Ｆ／Ｔ比值对前列腺癌诊断的特异性明显高于 ＰＡＳ。提示在总 ＰＳＡ４. ０～１０． ０ｎｇ／ｍｌ区间， Ｆ／Ｔ比值可明显提高前列腺癌与 ＢＰＨ的鉴别诊断能力。
By comparing the total free prostate specific antigen (PSA) and free / total prostate specific antigen ratio (F / T ratio) in 103 patients with prostate cancer and 98 BPH patients, this study showed that when all patients were included, the Prostate Cancer Group (P <0.01). However, when the total PSA was in the range of 4.0 ~ 10.0 ng / ml, the levels of total PSA in both groups were significantly higher than those in BPH group There was no significant difference between the two groups, but the F / T ratio of prostate patients was significantly lower than that of BPH patients (P <0.01). Analysis of sensitivity and specificity showed that in total PSA4. 0 ~ 10. In the 0ng / ml interval, the specificity of F / T ratio for the diagnosis of prostate cancer was significantly higher than that of PAS under the same sensitivity. Prompt in the total PSA4. 0 ~ 10. 0ng / ml interval, F / T ratio can significantly improve the differential diagnosis of prostate cancer and BPH.