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研究人员现已克隆一个基因,它可能是维尔姆斯瘤(占儿童所有肾癌的85％)的病因。在11号染色体上发现的候补基因有抑制肿瘤的特性;它只是鉴别的第三个这种抑制基因。然而,近来克隆的基因并未完全解决维尔姆斯瘤是如何发生的问题,因为有迹象表明,其他几个基因(有些甚至不是在11号染色体上)的变化可能与肿瘤的开始发生有关。在最近召开的美国人类遗传学学会年会上报告了假定的抑制基因的分离和定性。此项研究是由Kather Call领导的研究小组在马州理工学院的David Housman实验室中进行的。
Researchers have now cloned a gene that may be the cause of Wilm’s tumor, which accounts for 85% of all kidney cancers in children. The candidate gene found on chromosome 11 has the property of inhibiting tumors; it is only the third such suppressor gene identified. However, recently cloned genes have not completely solved the problem of how Wilm’s tumors occur because there are indications that changes in several other genes (some not even on chromosome 11) may be related to the onset of tumors. At the recent annual meeting of the American Society of Human Genetics, the hypothetical inhibitory gene was isolated and characterized. This research was conducted by Kather Call’s team at the David Housman lab at Massachusetts Institute of Technology.