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作者对1973至1985年间收治的204例急性髓系白血病(AML)患者中的94例作了回顾性研究,旨在探讨染色体和奥氏小体(Ar)与预后的联系。上述病例均系采用蒽环类抗生素和阿糖胞苷等进行诱导治疗,且初诊时染色体分析获得成功者。患者按有无Ar和异常克隆分为Ar~+、Ar~-、NN(只有正常分裂相)和AN(正常和异常分裂相并存)/AA(只有异常分裂相)共4组。将他们的完全缓解(CR)率和生存期资料加以比较,结果发现Ar~+者和有克隆性染色体异常者均占病例总数的48%(45/94);和Ar~-组相比,Ar~+组(不论染色体类型如何)其CR率较高,生存期也较长(P值均<0.02);NN组与AN/AA组的长期生存率无显著差别,但后1组的CR率和6个月生存率均低于前一组(P<0.02)。进一步分
The authors retrospectively studied 94 of 204 patients with acute myeloid leukemia (AML) admitted between 1973 and 1985 to investigate the relationship between chromosomes and auricules (Ar) and prognosis. The above cases were all induced by anthracycline antibiotics and cytarabine, and the chromosome analysis was successful at the initial diagnosis. Patients were divided into 4 groups according to whether there were Ar and abnormal colonies divided into Ar~+, Ar~~, NN (only normal dividing phase), AN (normal and abnormal dividing phase)/AA (only abnormal dividing phase). Comparing their complete remission (CR) rate and survival data, it was found that Ar~+ and clonal chromosome abnormalities accounted for 48% (45/94) of the total number of cases; compared with the Ar~~ group, In the Ar+ group (regardless of chromosome type), the CR rate was higher and the survival period was longer (P<0.02); the long-term survival rate of the NN group and the AN/AA group was not significantly different, but the CR of the latter group was not significant. The rate and 6-month survival rate were lower than the previous group (P < 0.02). Further points