本文调查了94个经手术证实的动脉导管未闭患者的一、二级亲属,并与372个正常的家系作对照。结果发现,患者一级亲属发病率(1.2％)显著高于对照一级亲属发病率(0);患者组二级亲属发病率为0.3％,明显低于一级亲属发病率。患者同胞215人中,5人患先天性心脏病,用Morton分离分析处理提示,动脉导管未闭患者存在遗传异质性。即绝大多数单纯型动脉导管未闭为多基因遗传,但也有少数病例由隐性遗传基因控制。 We investigated 94 surgically-confirmed patients with patent ductus arteriosus in first and second degree relatives and compared with 372 normal families. The results showed that the incidence of first-degree relatives in patients (1.2%) was significantly higher than that of first-degree relatives (0). The incidence of second-degree relatives in patients was 0.3%, which was significantly lower than that of first-degree relatives. Of the 215 patients with siblings, 5 had congenital heart disease, and Morton analysis indicated that there was genetic heterogeneity in patients with patent ductus arteriosus. That most simple patent ductus arteriosus for multi-gene inheritance, but there are a few cases controlled by recessive genes.