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目的:探讨ERα-29位基因多态性与HBV相关原发性肝癌(PHC)易感性的关系。方法:选择100例HBV相关原发性肝癌患者作为研究组,另选择100例健康体检者作为对照组。应用聚合酶链反应-限制性片段长度多态性法检测两组ERα-29位基因多态性。结果:研究组ERα-29位基因TT和TC基因型分布高于对照组,而CC基因型分布低于对照组,差异具有统计学意义(P<0.05);研究组T等位基因频率高于对照组,而C等位基因频率低于对照组,差异具有统计学意义(P<0.05)。T等位基因发生PHC的风险高于C等位基因(P<0.05)。结论:ERα-29位基因多态性与HBV相关原发性肝癌的易感性有关,其中T等位基因发生PHC的风险较高。
Objective: To investigate the relationship between ERα-29 gene polymorphism and the susceptibility to HBV-related primary hepatocellular carcinoma (PHC). Methods: One hundred patients with HBV-related primary liver cancer were selected as the study group, and another 100 healthy subjects were selected as the control group. Polymorphisms of ERα-29 gene in two groups were detected by polymerase chain reaction-restriction fragment length polymorphism. Results: The distributions of TT and TC genotypes of ERα-29 gene in study group were higher than those in control group, while the distribution of CC genotype was lower than that in control group (P <0.05). The frequency of T allele in study group was higher than Control group, while the frequency of C allele was lower than that of the control group, the difference was statistically significant (P <0.05). T allele PHC risk higher than the C allele (P <0.05). Conclusion: The polymorphism of ERα-29 gene is associated with the susceptibility of HBV-related primary hepatocellular carcinoma, and the T allele is associated with a higher risk of developing PHC.