论文部分内容阅读
本文报告1例20岁 Grave 氏病(突眼性甲状腺肿)的男性病人。过去无蛋白尿、肾病和药物反应史。在使用他巴唑治疗期间发生肾病综合征:全身水肿、1周内体重增加6kg,血压145/95,尿蛋白(册),有多量透明和颗粒管型,血尿素氮54mg/dl,肌酐2.0mg/dl,总蛋白4.4g/dl,白蛋白1.1g/dl,肌酐清除率60ml/mim 等。经皮作肾活检光学显微镜下显示肾小球接近正常,伴少置系膜突出,尚见小面积的肾小管萎缩与间质疤痕反应和炎症细胞浸润有关。两个肾小球的超显微结构研究显示上皮足细胞胞浆突的局灶性肿胀和范围达几个襻的足突融合。
This article reports a male patient with a 20-year-old Grave’s disease (Goiter). No past history of proteinuria, nephropathy and drug response. Nephrotic syndrome occurred during treatment with methimazole: systemic edema, weight gain within 6 weeks, blood pressure 145/95, urinary protein (albumin), amount of clear and granular tube, blood urea nitrogen 54 mg / dl, creatinine 2.0 mg / dl, total protein 4.4g / dl, albumin 1.1g / dl, creatinine clearance 60ml / mim and so on. Percutaneous renal biopsy under the light microscope showed glomerular near normal, with less prominent mesenteric, still see a small area of tubular atrophy and interstitial scar response and inflammatory cell infiltration. Supramolecular microscopic studies of both glomerulus show focal swelling of the cytoplasm of the epithelial podocyte and several 襻 foot processus fusions.