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１０名健康者，随机交叉口服单剂量（４０ｍｇ）尼卡地平普通片和缓释片后，利用ＨＰＬＣ法测定血浆中尼卡地平浓度，分别在１．６±０．３和３．５±０．２ｈ达到峰值１０９．８±３８．７和６３．１±１４．６μｇ·Ｌ－１，血药浓度曲线下面积分别为３５０．９±７２．３和３８９．６±８０．４μｇ·ｈ·Ｌ－１。１０名健康者，随机交叉口服多剂量尼卡地平普通片（每次２０ｍｇ，８ｈ一次）和尼卡地平缓释片（每次４０ｍｇ，１２ｈ一次）后，测得两种片剂稳态时的Ｃｍａｘ分别为７４．２±１５．８和８５．３±１８．９μｇ·Ｌ－１，Ｃｍｉｎ分别为９．４±２．４和１２．１±２．６μｇ·Ｌ－１。两者的血药浓度波动系数ＦＩ分别为１．５４±０．１２和１．４９±０．１１。经双单侧Ｔ检验法检验，两种片剂血药浓度曲线下面积具有等效性。
Ten healthy subjects were randomized to receive a single dose (40mg) of nicardipine tablets and sustained release tablets. The concentrations of nicardipine in plasma were determined by HPLC. The concentrations of nicardipine in plasma were 1.6 ± 0.3 and 3.5 ± 0 .2h reached the peak 109.8 ± 38.7 and 63.1 ± 14.6μg · L-1, the area under the plasma concentration curve were 350.9 ± 72.3 and 389.6 ± 80.4μg · h · L-1.10 healthy volunteers were randomized to receive oral administration of multiple doses of nicardipine (20 mg once every 8 h) and nicardipine sustained-release tablets (40 mg each time, once every 12 h) Cmax at steady state were 74.2 ± 15.8 and 85.3 ± 18.9 μg · L-1, respectively, and Cmin were 9.4 ± 2.4 and 12.1 ± 2.6 μg · L-1, respectively. The plasma concentration fluctuation coefficients FI of the two groups were 1.54 ± 0.12 and 1.49 ± 0.11, respectively. By double unilateral T-test, the area under the plasma concentration curve of two tablets has the equivalent.