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目的进行 gaslon N 预防和治疗实验性大鼠急性胃粘膜损伤的实验研究,以较全面地研究其对胃粘膜保护的机制。方法将48只 SD 大鼠分为3组。Ⅰ组为正常对照组。Ⅱ组为预防组,其中Ⅱ_a 为预防对照组,Ⅱ_b 为 gaslon N 预防组,Ⅱ_c 为雷尼替丁预防组。Ⅲ组为治疗组,同样分为3个亚组。用无水乙醇制备胃粘膜损伤动物模型。测定胃粘膜血流(GMBF)等多项指标。结果乙醇致大鼠胃粘膜损伤后,用gaslon N 预防和治疗与对照组比较均显著降低损伤指数(P 均<0.01),增加GMBF(分别为 P<0.01,P<0.05),升高胃粘膜电位(分别为 P<0.05,P<0.01),增加胃粘膜氨基己糖、磷脂含量(P 均<0.01),增强疏水性(分别为 P<0.05,P<0.01)。结论研究结果表明 gaslon N 是一种良好的胃粘膜保护剂。
Objective To study the prevention and treatment of gastron N in experimental acute gastric mucosal injury in rats and to study its mechanism of gastric mucosal protection in a more comprehensive way. Methods 48 SD rats were divided into 3 groups. Ⅰ group as normal control group. Ⅱ group for the prevention group, Ⅱ_a for the prevention group, Ⅱ_b for the gaslon N prevention group, Ⅱ_c for the ranitidine prevention group. Group Ⅲ for the treatment group, also divided into 3 subgroups. Animal models of gastric mucosal lesion were prepared with absolute ethanol. Determination of gastric mucosal blood flow (GMBF) and many other indicators. Results After gastric mucosal injury induced by ethanol, gastritis N prevention and treatment significantly decreased the injury index (P <0.01), increased GMBF (P <0.01, P <0.05, respectively) (P <0.05, P <0.01, P <0.01, respectively), and increased the contents of aminohexose and phospholipid in the gastric mucosa (all P <0.01) and hydrophobicity (P <0.05, P <0.01, respectively). Conclusion The results show that gaslon N is a good gastric mucosal protective agent.