乳房早发育是一种单一性乳腺发育的良性疾病,而特发性中枢性性早熟则为一种较严重的疾患;有进行性乳腺及阴毛发育、行为改变、生长及骨成熟加速、骨骺早闭。两者的治疗及预后不同。根据临床表现难以区别乳房早发育及早期中枢性性早熟。作者用测定血浆 Gn 基值及给 LHRH 刺激后Gn 反应的方法研究其在鉴别诊断上的意义。首先将58例特发性性早熟女孩分为6组。A 组15例,仅有乳腺发育;无阴毛、骨龄提前及生长加速。其中10例随诊5～25个月病程无进展,符合乳房早发育。B 组5例,乳腺发育及骨龄提前,但无阴毛及生长加速,其中3例随诊3～12个月亦无进展诊为可疑乳房早发育。C 组4例乳腺及阴毛已发 Breast early development is a benign disease of monomorphic breast development, while idiopathic central precocious puberty is a more serious condition; progressive breast and pubic hair development, behavioral changes, growth and accelerated bone maturation, epiphyseal early close. Both treatment and prognosis are different. According to clinical manifestations difficult to distinguish between early breast development and early precocious puberty. The authors used the determination of plasma Gn and LHRH stimulated Gn response after the method of its significance in the differential diagnosis. First, 58 cases of idiopathic precocious girls were divided into 6 groups. A group of 15 cases, only breast development; no pubic hair, bone age in advance and growth accelerated. Among them, 10 cases were followed up for 5 to 25 months and had no progress in their course of disease. They were consistent with early breast development. B group 5 cases, breast development and bone age in advance, but no pubic hair and growth acceleration, of which 3 cases were followed up for 3 to 12 months without progress was diagnosed as suspicious breast early development. C group 4 cases of breast and pubic hair have been made