论文部分内容阅读
近年来,关于脂加氧酶产物调节自然杀伤细胞(natural killer cell,NK cell)活性的报道逐渐增多,NK细胞与花生四烯酸(arac-hidonic acid,AA)代谢密切相关,而AA代谢产物在调节体内各种免疫细胞功能方面起着重要作用,脂加氧酶是AA的代谢途径之一,因此对于NK细胞与脂加氧酶产物之间关系的研究受到广泛重视。脂加氧酶产物对NK细胞活性的调节花生四烯酸经磷脂酶A_2 作用从膜上释放后,通过环加氧酶和脂加氧酶途径代谢。已有报道NK细胞活性与环加氧酶途径无关,而与
In recent years, reports on the regulation of the activity of the natural killer cell (NK cell) by the lipoxygenase product gradually increase. The NK cell is closely related to the metabolism of the arac-hidonic acid (AA), while the AA metabolite Plays an important role in regulating the function of various immune cells in vivo. Lipoxygenase is one of the metabolic pathways of AA. Therefore, the research on the relationship between NK cells and lipoxygenase products has received extensive attention. Regulation of NK Cell Activity by Lipoxygenase Products Arachidonic acid is metabolized by the cyclooxygenase and lipoxygenase pathways after it is released from the membrane by the action of phospholipase A 2. It has been reported that NK cell activity has nothing to do with the cyclooxygenase pathway