论文部分内容阅读
本文报告经直肠镜检或结肠活检证实的与氯林可霉素有关的伪膜性结肠炎47例,年龄15～87岁,其中13例(28％)原有的疾病为:癌肿5例,糖尿病4例,肌萎缩性侧索硬化、白血病、类风湿性关节炎、慢性肾功能衰竭各1例。用药途径:口服31例,静注8例,肌注1例,多种途径7例。11例(23％)用过其它抗菌素(先锋霉素14例,庆大霉素9例,氨苄青霉素2例,苯甲异噁唑青霉素1例),其中6例是在腹泻出现时或用1～2剂氯林可霉素后使用,35例(74％)单用氯林可霉素,另1例依次使用过林可霉素和氯林可霉素。起病经过:除1例以血性腹泻开始外,余均以水泻起病;伴痉挛性腹痛33例,发热37例(100～104°F);9例因腹部压痛、反跳痛和白细胞增加,曾一度疑有外科情况。本文伪膜性结肠炎患者据与用氯林可霉素的关系可分为两组:
This article reports 47 cases of pseudomyxal colitis confirmed by colonoscopy or colon biopsy, aged 15 to 87 years old, of which 13 (28%) of the original disease: cancer in 5 cases , 4 cases of diabetes, amyotrophic lateral sclerosis, leukemia, rheumatoid arthritis, chronic renal failure in 1 case. Route of administration: oral 31 cases, intravenous injection in 8 cases, intramuscular injection in 1 case, a variety of ways in 7 cases. Eleven patients (23%) used other antibiotics (14 for cephalosporins, 9 for gentamicin, 2 for ampicillin and 1 for penicillin), of which 6 were used in the presence of diarrhea or with 1 ~ 2 doses of clindamycin, 35 (74%) with clindamycin alone and the other followed lincomycin and clindamycin. After onset: except for one case of bloody diarrhea, Yu was diagnosed with watery diarrhea; with spastic abdominal pain in 33 cases, 37 cases of fever (100 ~ 104 ° F); 9 cases of abdominal tenderness, rebound tenderness and white blood cells Increased, once suspected of surgical conditions. Pseudomembranous colitis patients with clindamycin according to the relationship between can be divided into two groups: