γ-谷氨酰转肽酶(GGTP)是一种催化氨基酸间谷氨酰基团转递的酶。1979年Griffith及其同事认为,GGTP位于哺乳类动物细胞膜上。虽然它广泛分布于肾、肝、小肠及脑组织中,但当人体患有乳腺癌、乳腺炎或纤维腺瘤时则明显增高。此外,当培养的肝上皮细胞恶性转化时,此酶活性也显著增加,但在成纤维细胞以及非恶性的肝细胞中此酶活性并不改变。本文旨在阐明GGTP的改变是否与黑色素瘤的病变进展有关,以及它能否作为一种敏感的诊断指标。作者共测定了50例恶性黑色素瘤患者的血清γ谷氨酰转肽酶的水平。结果表明,18例患者在手术切除原发性病灶后,GGTP平均值为10.97 IU/L,与健康对照组(10.2±2.5;范围在5.56～15.2之间)不再有显著的差别。在8例经局部病灶及实体转 Gamma-glutamyl transpeptidase (GGTP) is an enzyme that catalyzes the transfer of glutamyl groups between amino acids. In 1979, Griffith and colleagues concluded that GGTP is located on mammalian cell membranes. Although it is widely distributed in the kidney, liver, small intestine and brain tissue, but when the human body has breast cancer, mastitis or fibroadenoma was significantly increased. In addition, this enzyme activity was also significantly increased when the cultured liver epithelial cells were malignantly transformed, but this enzyme activity did not change in fibroblasts and non-malignant hepatocytes. This article aims to elucidate whether changes in GGTP are associated with progression of melanoma and whether it can serve as a sensitive diagnostic indicator. A total of 50 malignant melanoma patients were measured serum γ-glutamyl transpeptidase levels. The results showed that after 18 surgical resections of the primary lesion, the mean GGTP was 10.97 IU / L, no significant difference from the healthy control group (10.2 ± 2.5; range 5.56-15.2). In 8 cases of local lesions and entities turn