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本文应用微量生物测定法观察超氧阴离子在慢性缺氧影响肺内动脉乙酰胆硷舒张反应中的作用。发现慢性缺氧可明显减弱大鼠肺内动脉的ACh内皮依赖性舒张,超氧化物歧化酶则可使此舒张反应恢复到正常水平。利用黄嘌呤—黄嘌呤氧化酶系统产生氧自由基(主要为O_2~((?))可削弱正常大鼠肺内动脉的ACh舒张反应,同样SOD可保护其免遭外源性氧自由基的损伤。结果表明慢性缺氧使肺血管氧自由基(尤其是O_2~((?))产生增多是大鼠肺内动脉ACh舒张反应受到损伤的原因之一。
In this paper, trace bioassay was used to observe the effect of superoxide anion on the relaxation of acetylcholine in pulmonary arteries by chronic hypoxia. Found that chronic hypoxia can significantly attenuate endothelium-dependent relaxation of ACh in the pulmonary arteries of rats, while the superoxide dismutase can restore this relaxation to normal levels. The use of xanthine - xanthine oxidase system to produce oxygen free radicals (mainly O_2 ~ ((?)) Can weaken the normal rat pulmonary artery ACh relaxation response, the same SOD can be protected from exogenous oxygen free radicals The results showed that chronic hypoxia caused pulmonary oxygen free radicals (especially O_2 ~ (?)) Increased production of ACh relaxation of pulmonary arteries in rats one of the reasons.