人们一直认为酶是唯一的生物催化剂,酶和生物催化剂概念具有等价性.Ribozyme的发现打破了这种等价性,生物催化剂上升为属概念,酶和ribozyme并列成为种概念.随着研究的深入,人们发现DNA也具有催化活性.本实验室对博莱霉素(BLM)的研究表明,BLM介导的DNA断链反应具有许多类似酶促反应的特性,并推测BLM和生物体内的许多辅酶可能是生物催化分子进化过程中保留下来的古老而简单的小分子生物催化剂.可以断言ribozyme并非唯一的非酶生物催化剂.“,”It has been considered that enzyme is the only biocatalyst for a long time, the concept of enzyme and biocatalyst is equivalent.The discovery of ribozyme broke out the equivalence, biocatalyst was up to a genus concept while enzyme and ribozyme became two paratactic species concepts.Recently people have found that DNA also has the catalytic ability.Some results from our study of bleomycin(BLM) indicate that, the reaction of DNA cleavage mediated by BLM shares many properties of the enzyme-catalyzed reaction.We speculate that BLM and many coenzymes are probably those simple antiquated micromolecules reserved from the evolution of biocatalysts.In conclusion, ribozyme is not the only non-enzyme biocatalyst.