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目的 :探讨含环孢素化学治疗方案治疗复发和难治性急性非淋巴细胞白血病的疗效。方法 :对 4 3例复发和难治性急性非淋巴细胞性白血病患者随机分为治疗组 (采用含环孢素的治疗方案 ,2 3例 )和对照组 (采用不含环孢素治疗方案 ,2 0例 )进行治疗 ,比较两组多药耐药的逆转情况。结果 :治疗组完全缓解率 5 2 % ,有效率 78% ,均高于对照组 (分别为 2 0 %、 4 5 % ,均为P <0 0 5 )。结论 :环孢素能够逆转难治性白血病的耐药性 ,用于治疗难治性白血病有良好的应用前景。
Objective: To investigate the efficacy of cyclosporine-containing chemotherapy in the treatment of relapsed and refractory acute non-lymphocytic leukemia. Methods: Forty-three patients with relapsed or refractory acute non-lymphocytic leukemia were randomly divided into treatment group (with cyclosporine-containing regimen, 23 cases) and control group (with cyclosporine-free regimen, 20 cases) were treated, compared with the reversal of multi-drug resistance in both groups. Results: The complete remission rate was 52% and the effective rate was 78% in the treatment group, which were significantly higher than those in the control group (20% and 45%, respectively, P <0.05). Conclusion: Cyclosporine can reverse the resistance of refractory leukemia, which has a good application prospect for the treatment of refractory leukemia.