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无环鸟苷是一核苷类抗病毒药物,选择作用于病毒感染的细胞,抑制病毒DNA的合成。对多种病毒有效,尤其对单疱病毒作用最强,且副作用小,是治疗眼科单疱病毒感染的一种较理想药物。一、药物动力学研究无环鸟苷可以多途径给药。以5mg/kg的剂量静脉给药,8小时一次,其血浆稳态平均峰值浓度可达9.7μg/ml,该浓度即能有效地作用于单疱病毒Ⅰ、Ⅱ、带状疱疹病毒、EB病毒;口服吸收不完全,生物利用度约15—30％,但是其吸收不受食物的影响。口服每次200 mg,每4小
Acyclovir is a nucleoside antiviral drug that acts on virally infected cells and inhibits viral DNA synthesis. Effective against a variety of viruses, especially for herpes simplex virus strongest, and the side effects of small, is the treatment of ophthalmic herpes simplex virus infection is a more ideal drug. First, pharmacokinetic studies Acycline guanosine can be administered in multiple ways. The dose of 5mg / kg intravenously, once every 8 hours, the steady-state plasma average peak concentration of up to 9.7μg / ml, the concentration that is effective in the herpes simplex virus Ⅰ, Ⅱ, herpes zoster virus, Epstein-Barr virus ; Oral absorption is not complete, the bioavailability of about 15-30%, but its absorption from the impact of food. Orally every 200 mg, every 4 small