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90%以上的癌症患者死于肿瘤转移,发生转移的癌症患者生存期一般不超过五年。癌症转移是癌细胞在体内扩散形成转移瘤,并伴随病人预后差。所以要控制癌症,首先得控制其转移,而关于促进和抑制转移的分子机理仍存在诸多问题,所以确定各种促进肿瘤转移的因素显得尤为重要。最近一篇发表在Science Translational Medicine上的文章比较了体内致癌因素(基因突变,基因组不稳定等),肿瘤微环境(血管和淋巴管的变
More than 90% of cancer patients die of tumor metastasis, cancer patients who metastasize usually have a survival period of no more than five years. Cancer metastasis is the spread of cancer cells in the body to form metastases, and with the poor prognosis of patients. Therefore, to control cancer, we must first control its metastasis. However, there are still many problems about the molecular mechanism of promoting and inhibiting metastasis. Therefore, it is particularly important to determine various factors that promote tumor metastasis. A recent article published in Science Translational Medicine compared in vivo oncogenic factors (mutations, genomic instability, etc.), tumor microenvironment (changes in blood vessels and lymphatics