白细胞介素(IL)-1β不仅对免疫系统,而且对造血、神经、内分泌等多个系统发挥多种生物学效应,是一个在机体防御方面起中心作用的细胞因子。IL-1β的异常表达往往与某些疾病密切相关,尤其在白血病的发生、发展中起着重要的作用。我们研究了乙酰豆寇佛波酯(TPA)对人单核细胞白血病传代细胞系U937细胞、人红白血病传代细胞系K562细胞、人T淋巴细胞白血病传代细胞系MT-2细胞中IL-1βmRNA表达的影响,从而探讨IL-1β与白血病细胞分化的相关性。材料和方法 Interleukin (IL)-1β exerts multiple biological effects not only on the immune system but also on hematopoietic, neural, and endocrine systems, and is a cytokine that plays a central role in the defense of the body. The abnormal expression of IL-1β is often closely related to certain diseases, especially in the occurrence and development of leukemia. We investigated the effect of acetylcholine phorbol ester (TPA) on IL-1β mRNA expression in human monocyte leukemia cell line U937 cells, human leukemia leukemia cell line K562 cells, and human T lymphocyte leukemia cell line MT-2 cells. To explore the correlation between IL-1β and leukemia cell differentiation. Materials and Method