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表皮生长因子受体(EGFR)是一种细胞膜受体,在病理状态下,EGFR可能存在自身激活,从而导致细胞的异常增殖,并在细胞的恶性转变过程中起重要作用[1 ] 。转化生长因子β(TGF β)是一组具有调节细胞生长和分化功能的超家族多肽,能与抑癌基因相协同,对上皮肿瘤产生强大的抑制效应。我
Epidermal growth factor receptor (EGFR) is a cell membrane receptor, under the pathological state, EGFR may exist self-activation, leading to abnormal cell proliferation and play an important role in the malignant transformation of cells [1]. Transforming growth factor β (TGFβ) is a group of superfamily peptides with functions of regulating cell growth and differentiation. It can cooperate with tumor suppressor gene and produce a powerful inhibitory effect on epithelial tumors. I