论文部分内容阅读
转化生长因子α(TGFα)是一种主要由肿瘤细胞产生的小肽分子,其前体为160个氨基酸,成熟体为50个aa残基,各种形式的TGFα均具有生物活性。TGFα为分泌性蛋白,它与细胞表面的表皮生长因子受体结合,以自分泌和旁分泌的形式参与对细胞增殖和分化的调节,TGFα与肿瘤密切相关,大多数肿瘤中已发现有TGFα高表达,TGFα具有肿瘤诊断、预后以及治疗临床外伤等多方面的应用价值。
Transforming growth factor α (TGFα) is a small peptide mainly produced by tumor cells. Its precursor is 160 amino acids and its mature body is 50 aa residues. All forms of TGFα are bioactive. TGFα is a secreted protein that binds to the epidermal growth factor receptor on the cell surface and participates in the regulation of cell proliferation and differentiation in an autocrine and paracrine manner. TGFα is closely related to the tumor, and TGFα is found in most tumors Expression, TGFα with tumor diagnosis, prognosis and treatment of clinical trauma and many other applications.