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本研究旨在探讨有脑血管病史的患者人口统计、健康及血管特征与认知损害的关系。用简易精神状态量表（Mini-Men-tal State Examination,MMS）检测122例至少于1月前发生过一过性脑缺血（TIA）或脑卒中的非残疾病人的认知功能,病人平均年龄59岁（41～79岁）,其中19％为女性。在零级相关分析中,MMS总分（27.74±3.91分）与年龄（r=-0.22）、受教育水平（r=0.52）、日常生活能力（r=0.48）、卒中后时间（r=-0.32）、收缩压（r=-0.24）及舒张压（r=-0.22）呈显著相关关系。多元回归分析显示MMS总分与受教育水平（教育水平每升高1级MMS增加0.62分,95％可信区间（CI）:0.35～0.89;P=0.0001）及日常生活能力显著相关（日常生活能力评分海增加1分,MMS增加0.47分;95％CI;0.02～0.93;P=0.03）.8例（7％）病人的MMS评分低于24分（定义为认知损害的界限值）,提示认知损害。在多因素Logistic回归分析中,认知损害的概率因日常生活能力受限而显著增加（条件相对危险度:44.98;95％CI=2.37～854.05;P=0.0001）。结果显示MMS评分与教育水平及日常生活能力相关,但认知损害只与有脑血管病史的病人的日常生活能力受限密切相关。
The aim of this study was to investigate the relationship between demographic, health and vascular characteristics and cognitive impairment in patients with a history of cerebrovascular disease. The cognitive function of 122 patients with non-disability who had transient ischemic attack (TIA) or stroke less than 1 month before were detected by Mini-Men-tal State Examination (MMS). The mean Age 59 years (41 to 79 years), of which 19% were women. In the zero - order correlation analysis, MMS score (27.74 ± 3.91) and age (r = -0.22), education level (r = 0.52), daily living ability (r = 0.48), post - stroke time 0.32), systolic blood pressure (r = -0.24) and diastolic blood pressure (r = -0.22). Multivariate regression analysis showed that the MMS score was significantly associated with daily living ability (education level 0.62, 95% confidence interval (CI): 0.35-0.89; P = 0.0001) for education level MMS scores increased by 0.47, 95% CI; 0.02-0.93; P = 0.03) .8 patients (7%) had a MMS score of less than 24 (defined as the threshold for cognitive impairment) Prompt cognitive impairment. In multivariable logistic regression analysis, the probability of cognitive impairment was significantly increased due to limited daily living ability (conditional relative risk: 44.98; 95% CI = 2.37-854.05; P = 0.0001). The results showed that MMS scores correlated with educational level and daily living ability, but cognitive impairment was only closely related to the limited daily living ability of patients with a history of cerebrovascular disease.