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目的探讨诱导痰、痰、血清中的白介素(IL)-4、-6、-8在慢性支气管炎急性期的浓度阈值,确定其诊断意义,了解三种白介素在三种标本中的不同浓度对诊断慢性支气管炎急性期的意义。方法 2001年1月8月对77例慢性反复咳嗽患者按全国慢性支气管炎诊断标准确诊慢性支气管炎急性期48例,非慢性支气管炎29例,进行IL-4、-6、-8的诱导痰、痰、血清检测。采用受试者工作特征曲线(ROC曲线)鉴定三种白介素对三种标本的诊断价值。结果①三种标本的三种白介素的诊断比值比(DOR)均>3,95%可信区间的下限均>1。②ROC曲线下面积显示:诱导痰及痰中IL-4、-8之间无差别(P>0.05),IL-4和IL-8分别与IL-6之间有统计学意义(P<0.05);血清中IL-4、-6、-8检测结果无差异(P>0.05)。IL-4、-8的诱导痰及痰与血清有统计学意义(P<0.05),IL-6的诱导痰、痰、血清之间无差异(P>0.05)。结论诱导痰及痰中的IL-4、-8诊断价值较好,可用于慢性支气管炎急性期的诊断。
Objective To investigate the concentration threshold of interleukin (IL) -4, -6, -8 in sputum, sputum and serum in the acute phase of chronic bronchitis, and to determine the diagnostic significance of these three interleukins in different concentrations of three kinds of samples Diagnostic significance of chronic bronchitis in acute phase. Methods Totally 48 chronic bronchitis patients and 29 non-chronic bronchitis patients were diagnosed in our hospital from January 2001 to August 2001 according to the national diagnostic criteria of chronic bronchitis. IL-4, -6, -8 induced sputum , Sputum, serum test. The receiver operating characteristic curve (ROC curve) was used to identify the diagnostic value of three interleukins in three specimens. Results ① The diagnostic odds ratios (DOR) of all three kinds of three kinds of samples were all> 3, the lower limit of 95% confidence interval was> 1. The area under the ROC curve showed that there was no difference between induced sputum and sputum (P> 0.05), IL-4 and IL-8 were significantly different from IL-6 (P <0.05) There was no difference in serum IL-4, -6, -8 (P> 0.05). IL-4, -8 induced sputum and sputum and serum were statistically significant (P <0.05), IL-6 induced sputum, sputum, serum no difference (P> 0.05). Conclusion Induced sputum and sputum IL-4, -8 diagnostic value is good, can be used for the diagnosis of chronic bronchitis in the acute phase.