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目的 探讨哮喘与慢性支气管炎 (慢支 )气道炎症性质的异同。方法 应用免疫组化技术 ,检测两组患者大气道粘膜嗜酸粒细胞阳离子蛋白特异性抗体 (EG1)、肿瘤坏死因子 (TNFα)、IL - 5、IL - 8的阳性细胞。结果 EG1、IL - 5阳性细胞数表达在哮喘组明显增高 ,IL - 8阳性细胞数表达在慢支组明显增高。结论 嗜酸性粒细胞活化及 IL - 5表达水平增高是哮喘性炎症的特点 ,而 IL - 8表达水平增高是慢支气道炎症的特点。
Objective To explore the similarities and differences of airway inflammation between asthma and chronic bronchitis (chronic bronchitis). Methods The positive cells of airway mucosal eosinophil cationic protein - specific antibody (EG1), tumor necrosis factor (TNFα), IL - 5 and IL - 8 were detected by immunohistochemistry. Results The expression of EG1 and IL - 5 positive cells in asthma group was significantly higher than that in chronic bronchitis group. Conclusion The activation of eosinophils and the increase of IL - 5 expression are the characteristics of asthmatic inflammation. The increased expression of IL - 8 is characteristic of chronic bronchitis.