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胆固醇逆向转运(reverse cholesterol transport,RCT)是促进外周胆固醇从细胞内流出,然后转运到肝脏进行代谢的过程,是机体抗动脉粥样硬化相关疾病的重要机制。研究表明,感染、炎症及创伤等诱导的急性期应答(acute phase response,APR)影响高密度脂蛋白的结构和功能,抑制细胞内胆固醇流出、血浆胆固醇转运及肝脏胆固醇代谢和排泌等环节,因此抑制体内RCT。APR短期抑制RCT有利于机体抗感染和组织损伤,然而,APR对RCT的进一步抑制将促进外周组织胆固醇蓄积及代谢紊乱,可能是多种感染免疫性疾病、代谢性疾病与动脉粥样硬化呈正相关的关键因素。本文就APR调节机体RCT的最新研究进展作一综述。
Reverse cholesterol transport (RCT) is a process that promotes the efflux of peripheral cholesterol from the cells and then to the liver for metabolism. It is also an important mechanism of anti-atherosclerotic disease in the body. Studies have shown that the acute phase response (APR) induced by infection, inflammation and trauma affects the structure and function of high density lipoprotein, the inhibition of intracellular cholesterol efflux, plasma cholesterol transport and hepatic cholesterol metabolism and excretion, Thus inhibiting in vivo RCT. Short-term inhibition of APR by RCT is good for anti-infective and tissue injury. However, further inhibition of RCT by APR will promote the accumulation of cholesterol and metabolic disorders in peripheral tissues. It may be a variety of immune-mediated diseases. Metabolic diseases are positively correlated with atherosclerosis The key factor. This review summarizes the latest research progress of APR in regulating body RCT.