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胃复安(Metoclopramide)是1961年合成的一种胃肠道兴奋剂。它敏化了胃肠道平滑肌对乙酰胆碱的作用,而不是直接作用于胆硷受体,能增强胃和食管蠕动,促进胃排空;促进幽门活动和十二指肠球部扩张;刺激催乳激素的释放。对中枢多巴胺受体有很强的阻断作用,可能是其广泛用于治疗多种原因引起的呕吐的药理学基础。我国于1971年仿制并广泛用于临床。本文着重综述其新用途和不良反应。一、临床应用1.用于难治性消化性溃疡:由于胃复安促进胃排空,缩短胃酸、胃蛋白酶与溃疡面的接触时间,减少胆汁对胃粘膜的损害,因此有利于溃疡愈合。有人选择对甲氰咪胍疗效不佳的20例溃疡患者(经胃镜和X线钡餐证实,病程最长20余年,最短
Metoclopramide is a gastrointestinal stimulant synthesized in 1961. It sensitizes the effect of gastrointestinal smooth muscle on acetylcholine rather than act directly on the cholinergic receptors, enhances gastric and esophageal motility, promotes gastric emptying, promotes pyloric activity and dilatation of the duodenal bulb, stimulates prolactin Release. It has a strong blocking effect on central dopamine receptors and may be the pharmacological basis for its extensive use in the treatment of vomiting caused by a variety of causes. My country in 1971 imitation and is widely used in clinical. This article focuses on its new uses and adverse reactions. First, the clinical application 1. For refractory peptic ulcer: due to metoclopramide to promote gastric emptying, shorten the gastric acid, pepsin and ulcer surface contact time and reduce the damage of bile gastric mucosa, thus contributing to ulcer healing. Some people choose to cimetidine ineffective 20 patients with ulcer (confirmed by endoscopy and X-ray barium meal, the longest duration of more than 20 years, the shortest