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给５４只Ｗｉｓｔａｒ雄性大鼠自由饮用染氟水，浓度分别为０．６（对照组），１００和２００ｍｇ／Ｌ，于染氟后第２、４、６周分批处死，测血清和肝组织的胆固醇、甘油三酯含量。结果显示，染氟第６周，染氟组大鼠血清胆固醇含量显著增高，肝组织胆固醇含量显著降低。２００ｍｇ／Ｌ摄氟组大鼠血清甘油三酯含量在第４周显著降低，肝组织甘油三酯含量在第６周显著降低。提示，氟可影响大鼠脂代谢，引起高胆固醇血症。
Fifty - four male Wistar rats were drank fluoride free water at a concentration of 0.6 (control group), 100 and 200 mg / L, respectively, and were sacrificed on the 2nd, 4th, 6th week after fluoride exposure. Serum and liver tissue Cholesterol, triglyceride content. The results showed that in the 6th week after fluoride exposure, the content of serum cholesterol was significantly increased and the content of cholesterol in liver tissue was significantly decreased. The level of serum triglyceride in 200 mg / L fluoride group decreased significantly at 4 weeks, and the content of triglyceride in liver tissue decreased significantly at 6 weeks. Tip, fluoride can affect lipid metabolism in rats, causing hypercholesterolemia.