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本文作者合成了雌酮和己烯雌酚的N-氮芥氨基甲酸乙醋类以及己烯雌酚的N-氮芥磷酰胺化合物,并进行了药理试验,结果发现这些化合物中仅雌酮的N-氮芥氨基甲酸乙酯(Ⅱ)稍有抗乳腺癌的作用,它的合成路线如下:
The authors synthesized estrone and diethylstilbestrol N-mustard carbamates and diethylstilbestrol N-nitrogen mustard phosphoramidate compounds and conducted pharmacological tests and found that these compounds only estrone N-nitrogen mustard carbamate Ethyl (II) slightly anti-breast cancer role, its synthetic route is as follows: