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最近一年多来,我們在寻找非銻剂抗血吸虫病药物方面,合成了一大类具有下列通式的化合物。在合成了的几百个这类型的化合物中,不少在动物試驗有显著的杀日本血吸虫效力。此类型的药物的化学通式为:
In the past year or so, we have synthesized a large group of compounds of the following general formula in the search for antimony-free anti-schistosomiasis drugs. Of the hundreds of compounds of this type that have been synthesized, many have shown significant efficacy against Schistosoma japonicum in animal experiments. The chemical general formula for this type of drug is: