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人体呼吸道病理学研究的主要任务之一是阐明鼻咽部菌群在流感后肺炎发病机理中的作用。关于这一点,从菌群的质和量的改变方面探索流感感染期间上呼吸道粘膜菌群的状况具有重要意义。本文报导47例确诊流感患者(分离到甲型/H_3N_2流感病毒)的鼻咽部细菌学检查的结果。最显著的改变见于鼻腔粘膜菌群。在发病头两天未见特殊改变,仅见金黄色葡萄球菌(SA)和酵母菌样霉菌(YLF)培养阳性率明显增高,分别为52.4%和19.2%。但在第3～4天鼻粘膜菌群发生显著改变:培养基中出现在健康人中找不到的溶血性和非溶血性链球菌;绿色链球菌(29.2%)和变形杆菌(16.7%)的阳性率增高,SA和YLF培养阳性率继续上升。这个病期的特征是许多微生物的培养阳性率最高。到第5～7天,临床症状消退,微生物培养阳性率亦显著
One of the main tasks of human respiratory pathology is to elucidate the role of nasopharyngeal flora in the pathogenesis of post-influenza pneumonia. In this regard, it is of great importance to explore the condition of upper respiratory tract mucosal flora during influenza infection in terms of changes in the quality and quantity of flora. This article reports the results of the nasopharyngeal bacteriological examination of 47 confirmed influenza patients (Influenza A / H_3N_2 influenza virus). The most significant change is found in nasal mucosal flora. In the first two days of the disease, no special changes were observed. Only the positive rates of Staphylococcus aureus (SA) and Yeast-like mold (YLF) were significantly increased, accounting for 52.4% and 19.2%, respectively. However, there was a significant change in the nasal mucosal flora on day 3 to 4: Hemolytic and non-hemolytic streptococci that were not found in healthy individuals appeared in the medium; Streptococcus viridans (29.2%) and Proteus (16.7%) The positive rate of SA and YLF culture continue to rise. This period of disease is characterized by the highest rate of culture of many microorganisms. To the first 5 to 7 days, clinical symptoms subsided, the positive rate of microbial culture is also significant