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This study was to explore the optimal threshold of thyroid-stimulating hormone(TSH)-stimulated serum thyroglobulin(s-Tg) for patients who were to receive ~(18)F-fluorodeoxyglucose(~(18)F-FDG) PET/CT scan owing to clinical suspicion of differentiated thyroid cancer(DTC) recurrence but negative post-therapeutic 131I whole-body scan(131I-WBS). A total of 60 qualified patients underwent PET/CT scanning from October 2010 to July 2014. The receiver operating characteristic(ROC) curve analyses showed that s-Tg levels over 49 μg/L led to the highest diagnostic accuracy of PET/CT to detect recurrence, with a sensitivity of 89.5% and a specificity of 90.9%. Besides, bivariate correlation analysis showed positive correlation between s-Tg levels and the maximum standardized uptake values(SUVmax) of ~(18)F-FDG in patients with positive PET/CT scanning, suggesting a significant influence of TSH both on Tg release and uptake of ~(18)F-FDG. So, positive PET/CT imaging is expected when patients have negative 131I-WBS but s-Tg levels over 49 μg/L.
This study was to explore the optimal threshold of thyroid-stimulating hormone (TSH) -stimulated serum thyroglobulin (s-Tg) for patients who were received ~ (18) F-fluorodeoxyglucose scan attributable to clinical suspicion of differentiated thyroid cancer (DTC) recurrence but negative post-therapeutic 131 I whole-body scan (131I-WBS). A total of 60 qualified patients underwent PET / CT scanning from October 2010 to July 2014. The receiver operating characteristic (ROC) curve analyzes that that s-Tg levels over 49 μg / L led to the highest diagnostic accuracy of PET / CT to detect recurrence, with a sensitivity of 89.5% and a specificity of 90.9%. Besides, bivariate correlation analysis showed positive correlation between s-Tg levels and the maximum standardized uptake values (SUVmax) of ~ (18) F-FDG in patients with positive PET / CT scanning, suggesting a significant influence of TSH both on Tg release and uptake of ~ F-FDG. So, positive PET / CT imaging is expected when patients have n egative 131I-WBS but s-Tg levels over 49 μg / L.