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目的研究急性脑梗死患者颈动脉粥样斑块与血清胆红素、C反应蛋白水平之间的关系。方法对162例急性脑梗死住院患者通过颈动脉彩色多普勒超声确定有无颈动脉斑块,根据结果分成斑块组(颈动脉IMT≥1.2mm和/或有颈动脉斑块)92例和无斑块组(颈动脉IMT<1.2mm且无颈动脉斑块)70例,同时测定血清胆红素、C反应蛋白水平,分析两组间血清胆红素及C反应蛋白水平的差异。结果两组间性别、年龄、血糖、血脂比较无显著差异(P>0.05),斑块组血清胆红素水平,尤其是间接胆红素水平明显低于无斑块组,有统计学意义(P<0.05)。斑块组血清C反应蛋白水平明显高于无斑块组,有统计学意义(P<0.05)。结论在急性脑梗死患者颈动脉粥样硬化的发生、发展中,血清胆红素水平与颈动脉粥样硬化病变呈负相关,而血清C反应蛋白与颈动脉粥样硬化病变呈正相关。
Objective To study the relationship between carotid plaque, serum bilirubin and C-reactive protein in patients with acute cerebral infarction. Methods A total of 162 acute cerebral infarction inpatients with carotid artery color Doppler ultrasound to determine the presence or absence of carotid artery plaque, according to the results were divided into plaque group (carotid IMT ≥ 1.2mm and / or plaque carotid artery) 92 cases and Serum bilirubin and C-reactive protein levels were measured in 70 patients without plaque (carotid artery IMT <1.2mm and without carotid artery plaque), and the differences of serum bilirubin and C-reactive protein between the two groups were analyzed. Results There was no significant difference in sex, age, blood glucose and blood lipids between the two groups (P> 0.05). The level of serum bilirubin, especially indirect bilirubin in plaque group was significantly lower than that in non-plaque group P <0.05). The level of serum C-reactive protein in plaque group was significantly higher than that in non-plaque group (P <0.05). Conclusions In the occurrence and development of carotid atherosclerosis in patients with acute cerebral infarction, the level of serum bilirubin is negatively correlated with carotid atherosclerosis. Serum C - reactive protein is positively correlated with carotid atherosclerosis.