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One new indoloditerpene,6,7-dehydropaxilline(1),one new indole-diketopiperazine,spirotryprostatin F(2),and one new 13-membered macrolide,N-demethylmelearoride A(3),as well as 8 known alkaloids(4-11),were isolated from the solid cultures of the endophytic fungus,Penicillium brefeidianum.The structures and absolute configurations of compounds 1-3 were elucidated by comprehensive spectroscopic analysis and the circular dichroism(CD) exciton chirality method.All the metablites were evaluated for their cytotoxic activites against three human tumor cell lines.Compound 2 exhibited cytotoxicities against HepG2 and MDA-MB-231 cells with IC_(50) values of 14.1 μmol/L and 35.5μmol/L,respectively.Compound 3 showed moderate activity against HepG2 cells with IC_(50) values of 36.6 μmol/L.
One new indole-diketopiperazine, spirotryprostatin F (2), and one new 13-membered macrolide, N-demethylmelearoride A (3) 11), were isolated from the solid cultures of the endophytic fungus, Penicillium brefeidianum. The structures and absolute configurations of compounds 1-3 were elucidated by comprehensive spectroscopic analysis and the circular dichroism (CD) exciton chirality method. All the metablites were evaluated as Their cytotoxic activites against three human tumor cell lines. Compound 2 exhibited cytotoxicities against HepG2 and MDA-MB-231 cells with IC 50 values of 14.1 μmol / L and 35.5 μmol / L, respectively. Compression 3 showed moderate activity against HepG2 cells with IC 50 values of 36.6 μmol / L.