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氯乙烯可引起多种疾病,迄今已报告有肝血管肉瘤、肢端骨质溶解、硬皮病样变化、肢端动脉痉挛现象、肺换气功能紊乱、门脉高压症、脾大和血小板减少症等。作者在一个化学工厂中见到7例氯乙烯单体(VCM)生产工人发生门脉高压症,年龄36～57岁,接触VCM气体时间4～15年。无1例有肝炎史,或接触肝脏毒物如砷剂,或服用对肝有毒性的药物史。食管静脉曲张呕血4例,发展为肝血管肉瘤1例,肝大6例,触及脾脏4例。肝功能试验呈非特异性轻度异常。血小板计数检查6例,5例减低,在39,000～80,000/立方毫米之间。脾内压升高4例,肝静脉楔压轻度升高2例。脾静脉造影,7例均有畅通的门静脉及食管静脉曲张,脾内静脉构型正常或接近正常者4例。剖腹探查见肝脏呈小结节状和硬化,但活检呈非硬化的纤维化4
Vinyl chloride can cause a variety of diseases, so far have been reported hepatic angiosarcoma, acral osteolysis, scleroderma-like changes, acral artery spasm phenomenon, pulmonary ventilation dysfunction, portal hypertension, splenomegaly and thrombocytopenia Wait. The authors observed seven patients with VCM in a chemical factory who developed portal hypertension, aged 36-57 years, exposed to VCM gas for four to 15 years. None of the patients had a history of hepatitis or had a history of exposure to liver poisons such as arsenic or taking drugs that were toxic to the liver. 4 cases of esophageal variceal hemorrhage, the development of hepatic angiosarcoma in 1 case, 6 cases of hepatomegaly, touching the spleen in 4 cases. Liver function tests showed non-specific mild abnormalities. Platelet count examination in 6 cases, 5 cases reduced, between 39,000 to 80,000 / cubic millimeter. 4 cases of elevated splenic pressure, mild hepatic venous wedge pressure in 2 cases. Splenic vein angiography, 7 cases were smooth portal vein and esophageal varices, splenic vein configuration normal or near normal in 4 cases. The laparotomy revealed a nodular and cirrhous liver, but the biopsy showed non-sclerosis fibrosis4