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目的探讨大鼠在工作记忆过程中,前额叶皮层多通道局部场电位(local field potentials,LFPs)θ频段的功能性连接特性。方法记录成年雄性SD大鼠在Y迷宫工作记忆过程中16通道LFPs,应用短时傅里叶变换进行时频分析。选取与工作记忆相关的θ频段,应用同步似然分析计算工作记忆过程中前额叶皮层16通道同步似然矩阵值S、聚集系数C、特征路径长度L,并与静息状态下进行比对。结果时频分析显示LFPs能量密度分布集中于红外打标点前1s至打标点处的θ频段。大鼠工作记忆过程中LFPsθ频段同步似然值Sp=0.6593±0.0220,静息状态下Sp=0.5104±0.0516。当T=0.76时大鼠工作记忆过程和静息状态下功能性连接差异最明显,具有统计学意义。工作记忆过程LFPsθ频段聚集系数Cp=0.2206±0.0263,明显高于静息状态Cp=0.1065±0.0237(P<0.05)。工作记忆过程LFPsθ频段特征路径长度Lp=1.3110±0.1318,明显低于静息状态Lp=2.9329±0.2763(P<0.05)。结论大鼠在工作记忆过程中LFPs的特征频段是θ,而且工作记忆过程中LFPs的功能性连接强于静息状态。
Objective To investigate the functional connectivity of the multi-channel local field potentials (θ) in the prefrontal cortex during working memory in rats. Methods The 16-channel LFPs of adult male Sprague-Dawley rats during Y-maze working memory were recorded and time-frequency analyzed by short-time Fourier transform. The θ frequency band associated with working memory was selected and the simultaneous likelihood matrix value S, clustering coefficient C, characteristic path length L in the prefrontal cortex during working memory were calculated by synchronous likelihood analysis, and compared with the resting state. Results The time-frequency analysis showed that the energy density distribution of LFPs focused on the θ band from 1 s before the marking point to the marking point. In the process of working memory, LFPsθ band synchronization likelihood value Sp = 0.6593 ± 0.0220, resting state Sp = 0.5104 ± 0.0516. When T = 0.76, the difference of functional connection between working memory process and rest state was the most obvious, with statistical significance. Working memory process LFPsθ band aggregation coefficient Cp = 0.2206 ± 0.0263, significantly higher than the resting state Cp = 0.1065 ± 0.0237 (P <0.05). The characteristic path length of LFPsθ band during working memory was Lp = 1.3110 ± 0.1318, which was significantly lower than resting Lp = 2.9329 ± 0.2763 (P <0.05). Conclusions The characteristic frequency band of LFPs during working memory in rats is θ, and the functional connection of LFPs in working memory is stronger than that in resting state.