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目的：探讨颗粒细胞瘤(granular cel tumor，GCT)的临床病理特征，组织学标准和鉴别诊断。方法对5例GCT进行临床资料回顾、病理形态观察及免疫组织化学检测。结果4例为良性、1例为不典型GCT。GCT形态学特征性表现为胞质丰富，嗜酸性颗粒状；1例不典型GCT部分细胞呈梭形，细胞核有异型。免疫组化显示肿瘤细胞呈S-100、NSE和vimentin弥漫阳性。结论 GCT为一种少见的软组织肿瘤，大部分为良性，临床表现和形态学上易与其他肿瘤混淆。恶性GCT镜下表现可与良性很相似，应用组织学标准并结合肿瘤的生物学行为综合考虑。“,”Purpose To investigate the clinicalpathological characteristics, the histologic criteria and differential diagnosis of granular celltumor (GCT). Methods The clinical and pathologic profiles of 5 cases GCTs were evaluated .Al the cases were studied by histopathological observation and immunohistochemical staining. Results The study included 4 cases of benign granular celltumor(BGCT)and 1 atypical granular celltumor(AGCT).The tumor was characterized by aboundant cytoplasm,ful of acidophilic granules.Immunohistochemical study demonstrated that tumor cels were reacted with S-100,NSE and vimentin.Conclusions Most of GCTs are benign.GCT can be misdiagnosed by clinical and morphological feature. Microscopicaly,malignant granular celltumor may closely r esembled its benign counterpart. The diagnosis relies on both histologic criteria and clinicopathologic correlation.