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Background: Paraneoplastic peripheral neuropathy is sometimes associated with unidentified neuronal autoantibodies. Objective: To examine the effects of serum from a patient with subacute sensory axonopathy on the function of the Trk high -affinity nerve growth factor receptor. Patient: An 86-year-old man with sens ory neuropathy exhibiting an autoantibody to Trk. Methods: Immunoblot analyses o f the brain homogenates and immunoprecipitation were performed with human sera. We further examined the effect of sera on nerve growth factor-induced neurite o utgrowth and Trk autophosphorylation. Results: The patient showed sensory nerve axonopathy without well-known paraneoplastic autoantibodies. His serum inhibite d nerve growth factor-induced neurite outgrowth and Trk autophosphorylation in PCtrk cells. Moreover, the patient’s serum, but not control serum, immunoprecip itated Trk and recognized Trk in brain homogenates as well as in Trk immunopreci pitates. Conclusion: These data strongly suggest that an anti-Trk autoantibody might cause subacute sensory neuropathy.
Background: Paraneoplastic peripheral neuropathy is sometimes associated with unidentified neuronal autoantibodies. Objective: To examine the effects of serum from a patient with subacute sensory axonopathy on the function of the Trk high -affinity nerve growth factor receptor. Patient: An 86-year-old man with sensory neuropathy exhibiting an autoantibody to Trk. Methods: Immunoblot analyzes of the brain homogenates and immunoprecipitation were performed with human sera. We further examined the effect of sera on nerve growth factor-induced neurite o utgrowth and Trk autophosphorylation. Results: The patient showed sensory nerve axonopathy without well-known paraneoplastic autoantibodies. His serum inhibite d nerve growth factor-induced neurite outgrowth and Trk autophosphorylation in PCtrk cells. Moreover, the patient’s serum, but not control serum, immunoprecipated it Trk and recognized Trk in brain homogenates as well as in Trk immunopreci pitates. Conclusion: These data strongly s uggest that an anti-Trk autoantibody might cause subacute sensory neuropathy.