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目的分析安徽省5例人感染高致病性禽流感病例特点,为防治提供科学依据。方法按照《人禽流感流行病学调查方案》,对病例进行个案调查,调查发病经过、治疗情况,实验室检测,可能的感染来源,传播途径及暴露因素等。结果 5例人感染高致病性禽流感初期临床表现主要为流感样症状,4例病例的气管分泌物分离出H5N1禽流感病毒,5例病例的气管分泌物禽流感病毒H5N1核酸均为阳性。1例有明确的病死家禽接触史,死禽也被证实感染禽流感病毒;2例虽有明确的病死家禽接触史,但死禽未被证实感染禽流感病毒;2例病例未发现明确的病死禽接触史;结论 5例病例均为实验室确诊病例;对人禽流感病例的诊断不能完全依据禽流感疫情存在与否;经过对5例人禽流感病例密切接触者的医学观察,没有发现人传人的现象;人禽流感的感染来源、传播途径和影响因素等问题尚待进一步研究。
Objective To analyze the characteristics of five human cases of HPAI in Anhui Province and provide a scientific basis for prevention and treatment. Methods According to “Epidemiological survey of human bird flu”, case investigation was conducted to investigate the incidence, treatment, laboratory tests, possible sources of infection, transmission routes and exposure factors. Results The initial clinical manifestations of 5 HPAI cases were mainly flu-like symptoms. H5N1 bird flu virus was isolated from tracheal secretions of 4 cases and H5N1 nucleic acid of tracheal secretions from 5 cases. One case had a clear history of dead poultry contact and dead birds were also confirmed to be infected with the avian influenza virus. Two cases of dead poultry were not confirmed to have been infected with avian influenza virus although there was a clear history of dead poultry contact. No clear disease was found in two cases Poultry contact history. CONCLUSIONS: All 5 cases are laboratory confirmed cases. The diagnosis of human bird flu cases can not be based on the existence of the bird flu epidemic. After medical observation of 5 cases of close contact with human bird flu cases, no human The phenomenon of human transmission, the source of infection, the route of transmission and the influencing factors of bird flu have yet to be further studied.