不育夫妇中50%系因男性生育机能障碍,这些人中大多可发现精子数减少,迄今尚无治疗特发性男子不育的方法,枸橼酸克罗米芬(CC)为常用的治疗男子不育的药物,自60年代开始用于临床,一般为25～100mg/天,连续用2～6个月。一些报告认为 CC 可增加精子计数和妊娠率,但另一些报告认为不能改善生育力。本文中作者用双盲法比较了安慰剂和 CC 对特发性精子减少的不育男子精子计数和生育力的影响。研究包括23例23～49岁男子,无全身疾病及精神病,夫妇未行避孕,但一年未孕。参与研究对象均符合下列条件:①三次精液检查精子计数为50～2000万/ml,精子形态正常,活力>10%;②血清黄体生成素(LH)、卵泡刺激素(FSH)、睾酮(T)和催乳激素(PRL)正常;③裉据病史、体检、基础体温、月经史、血孕酮(P)水平、输卵 Fifty percent of infertile couples are due to male fertility dysfunction, and most of these people find fewer sperm, so far no cure for idiopathic male infertility has been found. Clomiphene Citrate (CC) is commonly used to treat men Education of drugs, since the 60’s for clinical use, usually 25 ~ 100mg / day, continuous use of 2 to 6 months. Some reports suggest that CC may increase sperm counts and pregnancy rates, but others report no improvement in fertility. In this paper, the authors compared the effects of placebo and CC on sperm count and fertility in infertile men with idiopathic sperm decrease by double-blind method. The study included 23 23 to 49-year-old man without systemic disease and mental illness, the couple did not contraception, but a year without pregnancy. Participants in the study were eligible for the following conditions: ① three semen sperm count 50 ~ 20 million / ml, sperm morphology is normal, vitality> 10%; ② serum luteinizing hormone (LH), follicle stimulating hormone (FSH), testosterone ) And prolactin (PRL) were normal; ③ According to the history, physical examination, basal body temperature, menstrual history, blood progesterone (P)