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目的：研究丁咯地尔对去甲肾上腺素（ＮＥ）和谷氨酸（Ｇｌｕ）引起大鼠单个脑细胞内游离钙增高的影响。方法：应用ＡＲ－ＣＭ－ＭＩＣ阳离子测定系统测量细胞内游离钙（［Ｃａ２＋］１）．结果：细胞外钙为 １．３ ｍｍｏｌ·Ｌ－１，丁咯地尔 ０．ｌ，ｌ．０，１０．０μｍｏｌ·Ｌ－１对细胞静息［Ｃａ２＋］．无明显影响，对ＮＥ诱导的［Ｃａ２＋］增高明显抑制，对Ｇｌｕ 诱导的［Ｃａ２＋］ 增高具有一定的抑制作用。结论：丁咯地尔能抑制ＮＥ和Ｇｌｕ 引起的单个脑细胞游离钙增高。
Objective: To investigate the effect of buflomedil on NE and glutamate-induced increase of intracellular free calcium in single brain cells of rats. Methods: Intracellular free calcium ([Ca2 +] i) was measured using the AR-CM-MIC cation assay system. Results: Extracellular calcium was 1.3 mmol·L-1, buflomedil. l, l. 0,10.0μmol·L-1 resting cells [Ca2 +]. Had no significant effect on NE-induced [Ca2 +] increased significantly inhibited Glu-induced [Ca2 +] increased a certain degree of inhibition. CONCLUSION: Buflomedil can inhibit NE and Glu-induced elevation of free calcium in single brain cells.