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目的：探讨急性Ｄｉｅｌｄｒｉｎ（氧桥氯甲桥奈）中毒对Ｃ５７ＢＬ 小鼠纹状体多巴胺及其代谢产物含量的影响。方法：给３组小鼠分别喂食 Ｄｉｅｌｄｒｉｎ ５０ ｍｇ·ｋｇ－１体重、Ｄｉｅｌｄｒｉｎ ４０ ｍｇ·ｋｇ－１体重和等量的生理盐水，３ ｈ后处死小鼠，取纹状体匀浆用高效液相色谱－电化学检测法测定纹状体中多巴胺（ＤＡ）、５－羟色胺（５－ＨＴ）、高香草酸（ＨＶＡ）、５－羟基吲哚乙酸（５－ＨＩＡＡ）和去甲肾上腺素（ＮＡ）的含量。结果：喂食 Ｄｉｅｌｄｒｉｎ ５０ ｍｇ·ｋｇ－１体重能降低小鼠纹状体中 ＮＡ、ＤＡ及 ＨＶＡ的含量．结论：大剂量的Ｄｉｅｌｄｒｉｎ可影响小鼠纹状体中 ＤＡ的代谢．可能是致帕金森病的环境因素之一。
Objective: To investigate the effect of acute Dieldrin (Chlorhexidine bridge) poisoning on dopamine and its metabolites in C57BL mice. Methods: Three groups of mice were given Dieldrin 50 mg · kg-1 body weight, Dieldrin 40 mg · kg-1 body weight and the same amount of saline, respectively. After 3 h, mice were sacrificed and the striatum was homogenized with high performance liquid The contents of dopamine (DA), serotonin (5-HT), HVA, 5-HIAA and norepinephrine ) Content. Results: Dieldrin 50 mg · kg-1 body weight reduced the content of NA, DA and HVA in the striatum of mice. Conclusion: High doses of Dieldrin can affect DA metabolism in mouse striatum. It may be one of the environmental factors that cause Parkinson’s disease.