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目的：研究周围神经损伤后神经生长因子对运动神经元的保护作用。方法：采用定位、定量、定时的方法钳夹大耳白免右坐骨神经，于损伤处注射蛇毒 ＮＧＦ ４００ Ｂｕ·ｋｇ－１·ｄ－１，神经损伤术后 １，３，７ｄ和 ２，３，４，６，８周动态观察脊髓腰段伤侧第 Ⅸ板层外侧群的大型运动神经元的超微结构变化，并对线粒体体密度变化进行定量分析。结果：神经损伤术后对照组超微结构的改变比实验组明显加重，实验组超微结构的恢复比对照组快。结论；ＮＧＦ对神经损伤后脊髓前角运动神经元超微结构的恢复有促进作用，从而对运动神经元可起一定的保护和促进恢复作用。
Objective: To study the protective effect of nerve growth factor on motor neurons after peripheral nerve injury. Methods: The right sciatic nerve of the big ear was maxed out by means of positioning, quantitative and time-keeping method. The injured rats were injected with NGF 400 Bu · kg-1 · d-1, 1, 3, At 4, 6, 8 weeks, the ultrastructural changes of large-sized motor neurons in lateral lateral layers of the injured spinal cord at the injured side of spinal cord were observed. The changes of mitochondrial body density were quantitatively analyzed. Results: The ultrastructural changes in the control group after the nerve injury were significantly worse than those in the experimental group, and the recovery of ultrastructure in the experimental group was faster than that in the control group. Conclusion NGF can promote the recovery of ultrastructure of motor neurons in the anterior horn of spinal cord after nerve injury, which can protect and promote the recovery of motor neurons.