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目的探讨子宫颈癌切除术联合全盆腔照射的疗效及影响生存率的预后因素。方法回顾性分析77例根治性子宫颈癌切除术后联合全盆腔照射患者的临床资料,采用Kaplan-Meier法计算各亚组患者的生存率。各亚组生存率的比较应用Log-rank检验,预后的多因素分析采用Cox回归模型。结果随访时间为5～152个月,中位随访时间为33个月。全组患者1、3、5年的总生存率分别为89.5%、69.8%、51.9%。单因素分析显示患者年龄≤35岁、贫血、分期较晚、肿瘤直径≥4㎝、有淋巴结转移与预后差有关。多因素分析提示年龄、肿瘤直径、淋巴结是否转移是影响生存的独立预后因素。结论子宫颈癌切除术联合全盆腔照射患者的预后与多种因素有关,年龄是否≤35岁、肿瘤直径是否≥4cm、淋巴结是否转移是影响生存的独立预后因素。
Objective To investigate the curative effect of cervical cancer resection combined with pelvic irradiation and prognostic factors affecting the survival rate. Methods The clinical data of 77 patients who underwent radical mastectomy combined with pelvic irradiation were retrospectively analyzed. The Kaplan-Meier method was used to calculate the survival rate of each subgroup. The survival rates of each subgroup were compared by Log-rank test, and the multivariate analysis of prognosis was performed by Cox regression model. Results The follow-up time ranged from 5 to 152 months. The median follow-up time was 33 months. The overall survival rates at 1, 3 and 5 years were 89.5%, 69.8% and 51.9% respectively. Univariate analysis showed that patients ≤35 years of age, anemia, late stage, tumor diameter ≥ 4㎝, with lymph node metastasis and poor prognosis. Multivariate analysis showed that age, tumor diameter and lymph node metastasis were independent predictors of survival. Conclusions The prognosis of patients with cervical cancer combined with pelvic irradiation is related to many factors. Whether the age is ≤35 years, the diameter of the tumor is ≥4cm, whether lymph node metastasis is the independent prognostic factor of survival.