论文部分内容阅读
目的:探讨风湿免疫病患者血清中可溶性补体受体2(sCR2)的变化及意义。方法:采用ELISA法检测31例类风湿性关节炎(RA)、18例系统性红斑狼疮(SLE)和20例健康体检者血清中可溶性补体受体2的浓度。结果:RA和SLE患者sCR2水平均明显低于健康体检者(P<0.01),RA和SLE患者间无统计学意义(P>0.05)。sCR2与年龄和性别无关,在RA中与RF无关,在SLE中与C3无关,在RA活动期明显低于非活动期(P<0.05)。结论:在自身免疫病中由于疾病本身导致了血清中sCR2的减少,疾病的活动程度可能与sCR2血清水平有一定关系。
Objective: To investigate the changes of serum soluble complement receptor 2 (sCR2) in patients with rheumatic immune disease and its significance. Methods: Serum concentrations of soluble complement receptor 2 in 31 patients with rheumatoid arthritis (RA), 18 with systemic lupus erythematosus (SLE) and 20 healthy controls were measured by ELISA. Results: The levels of sCR2 in RA and SLE patients were significantly lower than those in healthy subjects (P <0.01). There was no significant difference between RA and SLE patients (P> 0.05). sCR2 has nothing to do with age and gender, has nothing to do with RF in RA, has nothing to do with C3 in SLE, and is significantly lower than inactive during RA (P <0.05). CONCLUSIONS: Serum levels of sCR2 are reduced in autoimmune diseases due to the disease itself, and disease activity may be related to serum levels of sCR2.