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目的:探讨血清孕酮和人绒毛促性腺激素(β-HCG)检测在先兆流产中的意义。方法:选择2009-03/2010-05确诊的早期先兆流产患者186例为实验组,另选取正常妊娠者57例为对照组。采用电化学发光法技术(ECL)检测孕酮(P),采用放射免疫分析法(RIA)检测人绒毛促性腺激素β-HCG,并对两组患者的临床治疗效果进行比较分析。结果:与正常对照组相比,先兆流产的实验组患者的孕酮和β-HCG水平均有所降低,差别具有统计学意义(P<0.05)。与此同时,与孕酮单独检测比较,孕酮和β-HCG联合检测的敏感性、阴性预测值以及正确诊断率均明显提高,差别具有统计学意义(P<0.05)。结论:血清孕酮和β-HCG检测对于预测和指导先兆流产具有极其重要的作用。
Objective: To investigate the significance of serum progesterone and human chorionic gonadotropin (β-HCG) in threatened abortion. Methods: 186 cases of early threatened abortion confirmed from March 2009 to May 2010 were selected as the experimental group, and 57 normal pregnant women were selected as the control group. The levels of progesterone (P) were determined by ECL and radioimmunoassay (RIA) was used to detect human chorionic gonadotropin β-HCG. The clinical effects of two groups were compared. Results: Compared with the control group, the progesterone and β-HCG levels in the experimental group were significantly lower than those in the control group (P <0.05). At the same time, the sensitivity, negative predictive value and correct diagnosis rate of progesterone and β-HCG were significantly higher than those of progesterone alone (P <0.05). Conclusion: Serum progesterone and β-HCG tests play an important role in predicting and guiding threatened abortion.