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目的探讨苏州地区儿童急性呼吸道副流感病毒3型(Pinf-3)感染流行与气候因素的相关性。方法连续四年对因呼吸道感染而住院的6655例儿童进行病毒病原学监测。运用直接免疫荧光法检测呼吸道分泌物中Pinf-3抗原。同时收集2006~2009年苏州地区月平均气温、月平均湿度、月总雨量、月总日照、月平均风速等有关气象资料。采用直线回归和逐步回归法研究病毒活性与气候因素的相关性。结果 Pinf-3检出率为2.75%,4年阳性率分别为2.31%、2.50%、3.32%和2.92%,年度间阳性率无统计学差异(P>0.05)。从季节分布来看,Pinf-3好发于春夏季,夏季明显高于冬季(4.50%vs.1.30%)(P<0.01)。Pinf-3阳性率与月平均气温呈正相关(P<0.01)。结论 Pinf-3流行活性与气候相关,尤其是气温对Pinf-3的流行活性影响最大。
Objective To investigate the relationship between prevalence of Pinf-3 infection and climatic factors in children in Suzhou area. Methods A total of 6655 children hospitalized for respiratory infection were enrolled in this study for viral etiology for four consecutive years. Direct immunofluorescence assay for detection of Pinf-3 antigen in respiratory secretions. At the same time collected from 2006 to 2009 in Suzhou monthly average temperature, monthly average humidity, total monthly rainfall, total monthly sunshine, monthly average wind speed and other relevant meteorological data. Linear regression and stepwise regression were used to study the correlation between virus activity and climatic factors. Results The positive rate of Pinf-3 was 2.75%. The positive rates of Pinf-3 at 4 years were 2.31%, 2.50%, 3.32% and 2.92% respectively. There was no significant difference in the positive rates of Pinf-3 between the two groups (P> 0.05). In terms of seasonal distribution, Pinf-3 occurred in spring and summer, but significantly higher in summer than in winter (4.50% vs.1.30%) (P <0.01). The positive rate of Pinf-3 was positively correlated with the monthly mean temperature (P <0.01). Conclusion The Pinf-3 epidemic activity is related to the climate, especially the temperature has the greatest influence on the Pinf-3 epidemic activity.