Leake在“药理学的科学现状”一女中曾提出,药理学的基本问题有四:(1)研究剂量与生物效应的关系;(2)研究药物的作用部位(Iocalization of drug action);(3)研究药物的吸收、分布、代谢的机制;(4)研究化学结构与生物作用的问题. 近来,有关药物作用机制的研究,逐渐由宏观进入微观,从组织器官整体机能水平,进入亚细胞及分 Leake, a woman in the “state of science in science,” suggested that there are four basic problems in pharmacology: (1) the relationship between dose and biological effects; (2) the study of the drug’s site of action (Iocalization of drug action; (3) to study the mechanism of drug absorption, distribution and metabolism; (4) to study the problem of chemical structure and biological action Recently, the research on the mechanism of drug action has gradually entered the micro-macro from the macroscopic level, And points