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高原药用植物——川西獐牙菜(Swertia mussotii Franch)注射剂及其有效成份芒果甙和总(口山)酮对模拟高原急性低氧肝损伤具有保护作用。大鼠于低压舱内模拟海拔8,000m 2小时造成急性低氧肝损伤。预先给大鼠腹腔注射川西獐牙菜注射剂6.5ml/kg,可以明显降低大鼠SGOT和肝溶酶体酸性磷酸酶的活力,同时降低肝总脂的含量。大鼠肝溶酶体体外温孵实验显示,川西獐牙菜注射剂,芒果甙和总(口山)酮有稳定溶酶体膜的作用,并直接对溶酶体酸性磷酸酶活力有抑制作用。
Highland Medicinal Plant - Swertia mussotii Franch injection and its active ingredient mangiferin and total colorantone have protective effects on acute hypoxic-liver injury in simulated plateau. Rats simulated acute hypoxic liver injury at a simulated altitude of 8,000 m 2 in a low-pressure cabin. Pretreatment of rats by intraperitoneal injection of Swertia chuanxie 6.5ml / kg, can significantly reduce the rat SGOT and liver lysosomal acid phosphatase activity, while reducing the total hepatic lipid content. Rat liver lysosome in vitro incubation experiments showed that Swertia chuanxie injection, mangiferin and total (Kusama) ketone stable lysosomal membrane, and directly on the lysosomal acid phosphatase activity inhibition.