血小板减少是速尿治疗的一种罕见并发症,我们曾遇2例肾性浮肿、尿毒症,使用大剂量速尿静脉滴注引起血小板减少,致皮肤出血及血尿,现报告如下。例1 男,47岁,因反复血尿16年、伴血压升高13年,诊断为先天性多囊肾、肾性高血压,于1982年1月19日入院。体查:血压180/120,心脏向左下扩大,心尖可闻Ⅲ级收缩期杂音,左右上腹可触及5×3和10×8cm包块,呈囊状,无明显压痛,下肢浮肿。尿蛋白(±),红细胞(++～+++),白细胞(-),BUN 42.6mg％,血小板11.4万,出血、凝血时间正常。入院后经降压药、止血剂及一般支持疗法,血压波动在180～230/100～120,血尿时隐时现。自1982年3月起,因尿少、面部及下肢浮肿,间断使用速尿 Thrombocytopenia is a rare complication of furosemide treatment, we have encountered two cases of renal edema, uremia, intravenous infusion of high-dose furosemide induced thrombocytopenia, skin hemorrhage and hematuria are reported as follows. Example 1 Male, 47 years old, due to repeated hematuria for 16 years, with elevated blood pressure for 13 years, diagnosed with congenital polycystic kidney disease, renal hypertension, admitted January 19, 1982. Physical examination: blood pressure 180/120, heart enlargement to the left, apex symphony Ⅲ systolic murmur, around the upper abdomen can reach 5 × 3 and 10 × 8cm mass, cystic, no tenderness, lower extremity edema. Urine protein (±), erythrocytes (++ ~ +++), white blood cells (-), BUN 42.6mg%, platelets 114000, bleeding, clotting time is normal. After admission by antihypertensive drugs, hemostatic agents and general supportive therapy, blood pressure fluctuations in the 180 ~ 230/100 ~ 120, hematuria is now hiding. Since March 1982, due to oliguria, facial and lower extremity edema, intermittent use of furosemide