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对34例病理学上诊断为坏死性肉芽肿和未分化癌的鼻腔和口烟环的肿瘤进行免疫组化研究。结果表明在21例进行了LCA、cytokeratinCK、Desmin，Vimentin以及NSE检测的肿瘤中后细胞呈LCA（＋）17例．CK（＋）3例和NSE（＋）1例；另13例中瘤细胞为UCHL－1（＋）8例和L26（＋）5例。18例未分化癌中13例为LCA（＋）．2例L26（十）。8例坏死性肉芽肿中7例为UCHL－1（＋）．1例L26（＋）。原诊断为恶性肿瘤的8例中L26（＋）2例,LCA（＋）4例以及UCHL-1（＋）1例。表明鼻腔、口烟环坏死性肉芽肿绝大多数是淋巴瘤．仅极少数是上皮来源的肿瘤。
An immunohistochemical study was performed on 34 cases of tumors with pathologically diagnosed necrotic granuloma and undifferentiated carcinoma. The results showed that 17 cases of LCA, cytokeratinCK, Desmin, Vimentin and NSE were detected in 21 cases with LCA(+). There were 3 cases of CK(+) and 1 case of NSE(+). In the other 13 cases, there were 8 cases of UCHL-1(+) and 5 cases of L26(+). Of the 18 undifferentiated carcinomas, 13 were LCA (+). Two cases of L26 (ten). Of the 8 cases of necrotizing granuloma, 7 were UCHL-1(+). One case of L26(+). The original diagnosis of malignant tumors in 8 cases of L26 (+) 2 cases, LCA (+) 4 cases and UCHL-1 (+) 1 case. Shows that most of the necrotic granuloma of nose and mouth ring is lymphoma. Only a few are epithelial-derived tumors.