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目的：研究叶下珠对人肝癌细胞ＳＭＭＣ７７２１的影响。方法：噻唑蓝（ＭＴＴ）还原法和氚标胸腺嘧啶核苷（３Ｈ－ＲｄＲ）掺入法观察叶下珠提取物对人肝癌细胞ＳＭＭＣ７２２１细胞活性及ＤＮＡ合成的影响。结果：经叶下珠提取物处理后，ＳＭＭＣ７７２１活力明显减弱，３Ｈ－ＴｄＲ掺入率明显降低，ＤＮＡ合成抑制率与药物剂量成线性关系。结论：叶下珠具有杀伤人肝癌细胞ＳＭＭＣ７７２１和抑制其增殖作用。
Objective: To study the effect of Ye Xiazhu on human hepatocellular carcinoma cells SMMC7721. METHODS: MTT-reduction and indole-thymidine (3H-RdR) incorporation were used to observe the effects of extracts from leaf under leaves on the activity and DNA synthesis of human hepatoma cells SMMC7221. RESULTS: The activity of SMMC7721 was significantly attenuated and the incorporation rate of 3H-TdR was significantly decreased after treated with the extract of Phyllanthus oligospermum. The inhibition ratio of DNA synthesis was linear with the dose of drug. CONCLUSION: Yabaxiazhu can kill SMMC7721 and inhibit its proliferation.